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Best JD, Berghmans S, Hunt JJFG, Clarke SC, Fleming A, Goldsmith P, et al

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398,399 Mild mitochondrial uncoupling with 2,4-dinitrophenol (DNP) reduces oxidative stress and improves mitochondrial function in PD and HD models

Six weeks of hypoxic treadmill exercise significantly increases Sirt3 expression in the skeletal muscle of C57BL/6J mice, followed by upregulating the levels of FOXO3a, SOD2, PINK1, and Parkin proteins, with no significant change in the expression of Drp1 proteins, which promotes the level of mitophagy, and consequently improves the synthesis of ATP and the activity of citrate synthase (CS) in the skeletal muscles and increases mitochondrial volume and number